Biology Of Wound Healing

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07:55:32 pm on December 24, 2013

Biology Of Wound Healing

Anyone who remembers his childhood scrapes has probably heard many times ‘Don’t pick that scab, you’ll just make it worse!’.
Wound Healing
Tissue damage triggers a quick blood clotting, and wounds are repaired by the creation of new epidermal cells.
When you remove a scab, you are also eliminating some of the newly regenerated tissues growing underneath, thereby messing with the healing mechanism.
What is Wound Healing?
A tissue wound via an incision is usually followed by bleeding.
The process of vasoconstriction and coagulation begins with clotted blood quickly impregnating the wound, leading to hemostasis, and after dehydration, a scab forms.
An influx of inflammatory cells follows, with the liberation of cellular secretions and mediators.
Angiogenesis (growth of blood vessels) and re-epithelization occurs and the accumulation of fresh cellular and extracellular components ensues.
The Wound Healing Mechanism in detail
Wound healing is a complex and dynamic mechanism of reconstruction of skin cell structures and tissue layers.
The mechanism of wound healing is made of various steps that lead to the formation of scar tissue in replacement of tissue that has been damaged.
The human adult wound healing mechanism can be studied into 3 great different phases:
1- the inflammatory phase 2- the fibroblastic phase 3- the scar maturation phase
The inflammatory phase occurs immediately after the injury and lasts about 6 days.
The fibroblastic phase occurs at the termination of the inflammatory phase and can last approximately 4 weeks.
Scar maturation begins at the first month and can last for years.
These three phases include various processes: chemotaxis (attraction of cells by chemical substances), phagocytosis, neocollagenesis, collagen degradation, and collagen remodeling.
Also, angiogenesis (restored cappilaries), epithelization, and the synthesis of new glycosaminoglycans (GAGs) and proteoglycans are essential to the wound healing sphere.
The culmination of these biological processes results in the replacement of normal skin elements with fibroblastic mediated scar tissue.
This mechanism can produce an exuberance of fibrous protein synthesis with a resultant hypertrophic scar, which by check here definition is confined to the wound area. Further exuberance can result in keloid formation where scar synthesis extends beyond the area of the original damage. Conversely, insufficient healing can result in atrophic scar formation like in stretch marks.
How to enhance the Wound Healing Mechanism?
Copper & Zinc as trace elements play an important role in the healing of acne lesions and in check here more information more details wound healing. These molecules and elements act as biological activators of both the elimination of dead and injured skin cells and the rejuvenation of healthy cells. And also destroy opportunistic micro-organisms that thrive in wounds, while at the same time reconstructing the web of blood vessels that enhance oxygenation and nutrition into the newly formed healthy cells.

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